Thromboelastometry (TEM) findings in disseminated intravascular coagulation in a pig model of endotoxinemia.

Detecting hypercoagulability in sepsis: thromboelastometry vs thrombomodulin-modified thrombin generation test

Introduction Overt disseminated intravascular coagulation (DIC) develops in half of the septic patients by the fifth day, leading to double mortality in sepsis. Hypercoagulability, inevitably present before depletion of clotting factors and platelets, is hardly detected by available screening tests [1,2]. This, in turn, prevents the development of targeted therapy at early stages of DIC. Global...

Disseminated Intravascular Coagulation in a Case of Brucellosis Misdiagnosed as Thrombotic Thrombocytopenia Purpura

Thromboelastometry‐guided blood transfusion in septic shock complicated with disseminated intravascular coagulation: a case report

Approximately 25-50% of septic patients develop disseminated intravascular coagulation. The thromboelastometry evaluates whole blood clot formation and dissolution in real time and has been considered for management of bleeding in diverse clinical conditions. We present a case of thromboelastometry-guided bleeding management of a septic shock patient with overt disseminated intravascular coagul...

Successful Resuscitation of Maternal Cardiac Arrest With Disseminated Intravascular Coagulation Guided by Rotational Thromboelastometry and Transesophageal Echocardiography: A Case Report

We present a case of maternal cardiac arrest during an elective cesarean delivery. Transesophageal echocardiography identified a large pulmonary artery mass, and guided resuscitation efforts. After return of spontaneous circulation, the patient developed disseminated intravascular coagulation with massive hemorrhage. Blood product selection and volume replacement were guided by rotational throm...

Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury.

Despite increasing use of prothrombin complex concentrate (PCC) to treat hemorrhage-associated coagulopathy, few studies have investigated PCC in trauma, and there is a particular lack of safety data. This study was performed to evaluate PCC therapy in a porcine model of coagulopathy with blunt liver injury. Coagulopathy was induced in 27 anesthetized pigs by replacing approximately 70% blood v...